Gland
Sertoli cells
The seminiferous support cells and barrier-forming epithelium
High-yield
Inhibin B participates in feedback on FSH. Fetal AMH promotes Müllerian duct regression, a pathway distinct from androgen action on other reproductive structures.
Overview
Sertoli cells span the seminiferous epithelium and surround developing germ cells. Junctions between neighboring cells divide basal from adluminal compartments, creating a regulated barrier rather than an impermeable wall. Their support is essential to organized sperm development.
Reference facts
- Location
- Within seminiferous tubules, extending from basement membrane toward the lumen among developing germ cells.
- Hormones
- Inhibin B and AMH, with age-dependent secretion; also produces local proteins such as androgen-binding protein, which is a carrier rather than a hormone.
- Blood supply
- Peritubular microvessels support exchange; Sertoli junctions regulate access to the adluminal compartment and developing germ cells.
- Innervation
- FSH and local androgen signaling regulate major functions, alongside germ-cell and paracrine influences.
- Function
- Nourishes and organizes germ cells, forms and remodels the barrier, clears residual cytoplasm and provides endocrine feedback.
Clinical correlation
Persistent Müllerian duct syndrome can result from impaired AMH production or receptor signaling. Androgen insensitivity alone usually leaves AMH-mediated regression intact. AMH and inhibin B can provide information about Sertoli function in an appropriate developmental and clinical context.
Frequently asked questions
Where are the sertoli cells located?
Within seminiferous tubules, extending from basement membrane toward the lumen among developing germ cells.
What do the sertoli cells secrete?
Inhibin B and AMH, with age-dependent secretion; also produces local proteins such as androgen-binding protein, which is a carrier rather than a hormone.
What do the sertoli cells do?
Nourishes and organizes germ cells, forms and remodels the barrier, clears residual cytoplasm and provides endocrine feedback.
What is the blood supply of the sertoli cells?
Peritubular microvessels support exchange; Sertoli junctions regulate access to the adluminal compartment and developing germ cells.